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. and 1 1 did not yield a sigmoidal behavior (data not shown)
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. We deeply thank both reviewers for their criticisms, ideas, and suggestions
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. The intrinsic quenching of molecular rotors makes them sensitive to intrinsic rotational relaxation, which is slowed down during binding to aggregated protein
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. Interestingly, the activation energy E^sub a^ = 60 ± 8 kcal/mol of the slow heat-unfolding phase in apoA-2:DMPC disks (Fig
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. 2, but also indicates that contributions to larger values (including the nonclassical range Φ > 1) may arise from nonnative interactions with that residue that serve to restrict the folding space
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. semifasciata is also targeted by sport anglers and spear fishermen and represents a tourist attraction for recreational divers
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. At 12O0C, we visually observed a small amount of undissolved IPP polymer granules
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. The mixture were then injected subcutaneously into BALB/c female mice (4 weeks of age)
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. Hence, the helical junction geometry strongly affects the tertiary folding of the hairpin ribozyme
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