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" Is Carter so rigidly certain of his rectitude that he believes himself exempt from his own preaching?In a recent Los Angeles Times opinion piece defending his new book (and insinuating that the debate over it is being controlled by pro-Israeli lobbyists), Carter wrote that he is merely seeking a "free and balanced discussion of the facts
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. The large amounts of ACYI in these tissues suggest that it might play an important role in intracellular metabolism
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. This result is, to some extent, consistent with the predicted ACYI structure (17)
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. In the following sections, we show that the differences in Kratky profiles imply that in the EV limit proteins are cigar-shaped, loosely packed coils, with average topologies that are independent of amino acid sequence
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. Quenching experiments In experiments aimed to detect protein self-association, the concentration of EI^sup sc^ was varied at pH 7 from 0
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. These changes in the thermodynamical parameters point to subtle conformational variations in the packing of some residues
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. IENS is, therefore, well suited for experimental investigations of thermal fluctuations within biological macromolecules under different biochemical conditions on timescales that match those of MD theoretical calculations
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. We do not, therefore, see a fundamental contradiction between our experimental results and the MD simulations
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. A novel target recognition revealed by calmodulin in complex with the basic helix-loop-helix transcription factor SEF2-1/E2-2
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. 2-4, the osmotic pressure determined using the osmotic stress technique is plotted as the dimensionless compressibility factor, Π/ρk^sub B^T, as a function of protein mass fraction for pH 8
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. In the solutions containing 100 mM NaCl and 10 mM acetate buffer alone, this interaction becomes increasingly attractive at short range
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. Direct observation of the coil-globule transition in DNA molecules
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. The objectives of the research [14] reported in this paper are to produce toners using binders with high flexibility (low T^sub g^ and high elongation) and to evaluate the properties of fabrics printed with these toners
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. However, when a polymer-solvent system undergoes LLPS prior to crystallization in a certain range of polymer concentration (see Figure 1), the crystallization curve is modified
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. In the diffusion spFRET measurements described in this article, by labeling the ends of the loop-bearing arms with donor and acceptor dyes, we use the FRET efficiency E as an indicator of the distance between arms A and B of the ribozyme during the docking process
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. In contrast all thermal unfolded states (with the exception of those obtained from PPA) exhibit λ^sub max^ values around 340 nm, which correspond to much smaller red shifts upon unfolding
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.Detection and Characterization of Aggregates, Prefibrillar Amyloidogenic Oligomers, and Protofibrils Using Fluorescence SpectroscopyLindgren, MikaelABSTRACTTransthyretin (TTR) is a protein linked to a number of different amyloid diseases including senile systemic amyloidosis and familial amyloidotic polyneuropathy
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. Denaturing urea gel electrophoresis followed by quantification of RNA bands using phosphorimager analysis and determination of the ratio of cleaved to uncleaved substrate strand as a function of time provided ribozyme activity information
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