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. When the sample was heated up to 90°C, immediately cooled, and reheated, the reheating scan had no thermal effect over the temperature range of 30°C-90°C, which suggested that the thermal denaturation of ACYI was fully irreversible
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.Fluorescence resonance energy transfer (FRET) is a very informative technique for studying the tertiary folding of the hairpin ribozyme
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