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. INTRODUCTION Posttranslational modification is one of those events in biology that not only adorn a protein with variety but also impart it with different physicochemical properties
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. This feature is shared with Gaussian chains (39), although clear differences exist in the magnitude of and correlation between conformational fluctuations
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. The experimental results indicate that at physiological pH, the dimeric EI^sup SC^ had a well-folded structure; however, at low pH, EI^sup SC^ showed a partially unfolded state with the features of a molten globule, as suggested by fluorescence, far-ultraviolet circular dichroism, FTIR, and 8-anilino-1-naphthalene-sulfonic acid binding
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. Cholinesterases belong to the α/β hydrolase fold family (19)
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. Here we report a study of the backbone dynamics by ^sup 15^N-spin relaxation on the CaM dimer in complex with a dimeric peptide that mimics the CaM binding region of the bHLH transcription factor SEF2-1
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. We find that the association of Gβ86-105 to PLCβ gives a volume change that is similar to the full Gβγ-subunit
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. , 2003a) clearly show that variations in the disk diameter from 9 to 18 nm have no significant effect on the disk stability
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. of Physiology and Biophysics, Boston University School of Medicine, W329, 715 Albany St
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. CONSEQUENCES OF HIGH-DIMENSIONAL SEARCHESWe have identified two general predictions of this high-dimensional view of folding: 1), the sequential diffusive exploration of low-dimensional subspaces favored by fast folding; and 2), the suggestive stabilization of these subspaces by discriminate but nonnative (or near-native) interactions, without recourse to long-range guiding forces
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. RELATIONSHIP TO OTHER MODELSWe stress that the search-space picture explored above is not incompatible with the frameworks or results of the other models discussed in the introduction, but rather serves to show how the apparently alternative models are related, and how high-dimensional features are implicit in all of them
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. We also thank Atila Gosztonyi, Raul Gonzalez, and two anonymous reviewers for providing useful comments on the manuscript
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. The more protracted the reproductive period, the greater the likelihood that some spawning will occur during conditions favorable for larval survival (Lambert, 1990)
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. 747ErrorRelative fecundity (basedon prefertilization oocytes)Equality of slopes0
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. RNA folding: models and perspectives
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