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. the data in Fig
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. These models have an ad hoc flavor and are anchored in Flory's random-coil paradigm, where local biases are modeled accurately and long-range interactions are either ignored or modeled using a mean field
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. Due to the high sensitivity of tryptophan fluorescence with respect to changes in the microenvironment of the intrinsic chromophores, various properties of the unfolded state can have a distinct effect on the λ^sub max^-values
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. , close to the active-site gorge), while at the same time increasing fluctuations in some other part of the protein (see
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. An alternative explanation is that in this concentration range, the presence of an interfacial layer of protein has a marked influence on the observed rheology
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