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. This is a result of correlations that exist on all length scales and the fact that interactions that give rise to these correlations are purely repulsive in nature
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. We attempted, by docking of the EIN^sup sc^ and EIC^sup sc^ domains, to model the whole structure of EI^sup sc^ trying to keep the active-site histidine (in the EIN^sup sc^ domain) close to the PEP binding site (in the EIC^sup sc^ domain)
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. Such a correlation diagram of R^sub ex^ and ΔR^sub ex^ is shown in Fig
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. Two aspects of this type of binding as compared to rigid binding are important to discuss, the presence of fast exchange, and the effect on high affinity and specificity
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. Although DNA cannot be condensed by monocations in aqueous media (Wilson and Bloomfield, 1979), in a crowded environment DNA condensation is promoted by an increase in the concentration of monocations (Livolant and Amelie, 1996)
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